The Institute finances all necessary services under its responsibility with the Legislative decree no. 270, June 30  1993.

Finances come not only from  the National Health Service, but also from the Ministry of Health, to carry out current and finalised research projects in veterinary subject areas; further work is financed by regional or national grants. Other finances are available from the sales of sera and vaccines produced, consultancy services, and the voluntary contributions of public and private institutions and associations, to help with the work the Institute organizes to protect the  zoo-technical population  and control food of animal origin.. As stipulated by the Sicilian Regional law no.26 of December 18th, 2002, implementing economic-livestock accounting and analytical accounting on cost centres, has led to an improvement in the evaluation of several financial aspects of the Institute; this has also allowed the institute to channel resources into the more profitable activities, both for public and social benefit (which is, after all, the ultimate purpose of the Institute) and  financially for  the Institute .

Public grants from the Ministry of Health in the last 5 years rose from 6.014 € in 1997 to 11.267 € in 2002. These grants were employed in the development and upgrading of work done for public and private customers, and in increasing the number of employees, guaranteeing an improvement in the service.

Self-financing represents 10% of total funding, and is attributable to the production and sales of sera and vaccines, but also to the income from health projects, for example, eradication projects for brucellosis and bovine leucosis. Other financial sources result from all kinds of diagnostic tests performed (serological, parasitological, microbiological, chemical, virological etc.) There is no income connected to the use of the institute’s livestock as an economic resource, and any administrative surplus is employed in technical-scientific investment for the continual promotion of  scientific research.  
Personnel costs represent  50% of total costs; this expense has tripled in the last 3 years, increasing from  3.124 € in 1999 to 9.021 in 2002, in order to bring staff levels up to the level required to cope with operational needs.  Goods and services represent on average 30% of total costs , and they are constantly controlled to maximize efficiency.